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The use of Tramadol in clinical practice

Tramadol - the fourth most commonly prescribed analgesic in the world – used to treat both cancer and non-cancer pain in 70 countries around the globe.

At the medical literature, Tramadol is shown as an opioid agonist, standing alone among all other drugs of this class of opioids, primarily because unlike them it does not belong to addicting drugs. Tramadol medication is counted rather strong agent and should be taken only according to doctor’s prescription.

So, let us see in details what is Tramadol and its mechanism of action. The mechanism of Tramadol analgesic action is not completely identical to the mechanism of action of other opioid agonists. In contrast, Tramadol dosage has a dual mechanism of action.

Due to weak opioids and secondary effects of non-opioid analgesics Tramadol refers to the average action drug. The unusual dual mechanism of Tramadol action appeares because of its analgesic molecules activates on m-opioid receptors. In this case, the affinity of Tramadol for these receptors in a 6000 times weaker than morphine, so Tramadol addiction potential is minimal.

Experimental and clinical studies have shown that the ability to cause psychic and physical dependence with Tramadol 50mg is virtually absent. In the practice of European clinicians who use the drug in the late 70-ies of XX century, the abuse of Tramadol was very rare.

Tramadol is a fairly safe drug, since its analgesic dose did not lead to violation of the vital functions. Approximately in half cases Tramadol side effects are not observed.

The published data allow us to recognize Tramadol as comfortable enough medication to correct the various manifestations of acute and chronic pain from moderate to severe intensity, not only in cancer but also in rheumatology.

Visiting a doctor, patient can buy Tramadol according his prescription at specialized street pharmacies, or easy order Tramadol online.